4-27-17
| Round 1 | Team | Pos | Name | School |
| 1) | CLE | QB | Mitch Trubisky | North Carolina |
| 2) | SF | DE-OLB | Myles Garrett | Texas A&M |
| 3) | CHI | DE-OLB | Solomon Thomas | Stanford |
| 4) | JAC | RB | Leonard Fournette | LSU |
| 5) | *TEN | CB | Marshon Lattimore | Ohio State |
| 6) | NYJ | Te | O.J. Howard | Alabama |
| 7) | LAC | SS | Jamal Admas | LSU |
| 8) | CAR | RB-ATH | Christian McCaffery | Stanford |
| 9) | CIN | DL | Jonathan Allen | Alabama |
| 10) | BUF | Wr | Mike Williams | Clemson |
| 11) | NO | DE | Derek Barnett | Tennessee |
| 12) | *CLE | DB | Marlon Humphrey | Alabama |
| 13) | AZ | LB | Haason Reddick | Temple |
| 14) | *PHI | Wr | John Ross | Washington |
| 15) | IND | CB-Nic | Gareon Conley | Ohio State |
| 16) | BAL | Wr | Corey Davis | Western Michigan |
| 17) | WSH | FS | Malik Hooker | Ohio State |
| 18) | TEN | CB-ATH | Adoree’ Jackson | USC |
| 19) | TB | RB | Dalvin Cook | Florida State |
| 20) | DEN | OT | Ryan Ramczyk | Wisconsin |
| 21) | DET | DE | Charles Harris | Missouri |
| 22) | MIA | QB-A | Deshaun Watson | Clemson |
| 23) | NYG | Te | David Njoku | Miami |
| 24) | OAK | CB-DB | Kevin King | Washington |
| 25) | HOU | QB-A | Patrick Mahomes | Texas Tech |
| 26) | SEA | LT | Cam Robinson | Alabama |
| 27) | KC | DB-ATH | Jabrill Peppers | Michigan |
| 28) | DAL | CB-Nic | Tre’Davious White | LSU |
| 29) | GB | DE | Takkarist McKinley | UCLA |
| 30) | PIT | DL | Jordan Willis | Kansas State |
| 31) | ATL | OG-OC | Forrest Lamp | Western Kentucky |
| 32) | *NO | MLB | Reuben Foster | Alabama |
